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| LAB PROFILES |
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Chemosensitivity Test
(susceptibility to chemotherapy
agents) |
| SAMPLE |
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blood |
| DEFINITIONS |
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The goal of all chemosensitivity tests is to determine the response of a patient's cancer cells to
proposed chemotherapy agents. Knowing which chemotherapy agents the patient's cancer cells are
resistant to is important. Then, these options can be eliminated, thereby avoiding the toxicity of
ineffective agents. In addition, some chemosensitivity assays predict tumor cell sensitivity, or which
agent would be most effective. Choosing the most effective agent can help patients to avoid the
physical, emotional, financial costs of failed therapy and experience an increased quality of life. All
available chemosensitivity assays are able to report drug ""resistance" information. Resistance implies
that when a patient's cancer cells are exposed to a particular chemotherapy agent in the laboratory,
the cancer cells will continue to live and grow. Some chemosensitivity assays also are able to report
drug "sensitivity" information. Sensitivity implies that when a patient's cancer cells are treated with a
particular chemotherapy agent in the laboratory, the agent will kill the cancer cells or inhibit their
proliferation. |
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| LAB PROFILES |
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Tumor M2PK (colon cancer) |
| SAMPLE |
|
stool |
| DEFINITIONS |
|
Tumor M2-PK is a synonym for the dimeric form of the pyruvate kinase isoenzyme type M2 (PKM2).
Tumor M2-PK is a key enzyme within tumor metabolism and can be used in stool (fecal) samples for
the screening of colorectal tumors (bowel cancer) and in EDTA plasma samples for the follow-up of
various cancers. Tumor M2-PK is not an organ-specific tumor marker, such as PSA. As a biomarker the
amount of Tumor M2-PK in stool and EDTA-plasma reflects the specific metabolic status of the colonic
intestinal mucosa. |
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